Plasma

  • Plasma is the liquid part of blood.
  • Serum is the liquid that separates from clotted blood (plasma without clotting factors).
  • Lymph is the fluid within lymphatic vessels (mostly plasma and white blood cells).
  • The blood contains important proteins: albumin, globulins, and fibrinogen.
  • Serum albumin makes up more than half of plasma proteins.
  • Albumin is a major contributor to the osmotic pressure of plasma.
  • Albumin is produced in the liver and transports fatty acids and some lipid-soluble hormones and drugs.
  • Globulins make up about 35% of plasma proteins, including immunoglobulins (antibodies) and transport proteins.
  • Fibrinogen is converted to insoluble fibrin strands by thrombin during blood clotting.
  • Soluble organic nutrients in the blood include glucose, fatty acids, amino acids, and wastes (such as urea).
  • Triglycerides and cholesterol are not soluble in plasma, so are carried with lipoproteins (lipid/protein complexes).
  • The major buffer in blood is bicarbonate, with a pH between 7.35 and 7.45.
  • The major ions in blood are sodium and chloride.

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